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Young knew that Lilly, which manufactures synthetic insulin, had been working on its own peptide hormone

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In SURMOUNT-1, adults with obesity (without diabetes) lost an average of 15.0%, 19.5%, and 20.9% of body weight with tirzepatide 5 mg, 10 mg, and 15 mg respectively over 72 weeks, compared to 3.1% with placebo

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Additionally, PCs alleviated DN pathology, such as glomerular basement membrane thickening and central dilatation, by modulating mimecan protein expression through the NF-B p65 pathway (Zhou et al., 2016) (Figure 8)

Methods 20 , 11791182 (2023)